Oncology CPT Codes for 2024 + Modifiers

If your oncology codes are incorrect, you could delay or even miss collections, reducing profits. Inaccuracy in billing could even trigger an audit. Make sure you’re up to date on the latest codes to maximize collections.

Oncology CPT Code Ranges for 2024

Here are oncology center CPT codes for 2024:

• 0269U – genomic sequence analysis for autosomal dominant congenital thrombocytopenia, examining 22 genes, from samples of blood, buccal swab, or amniotic fluid.
• 0404T – ablation of uterine fibroids using radiofrequency, guided by transcervical ultrasound.
• 58580 – transcervical ablation of uterine fibroids, including radiofrequency and intraoperative ultrasound guidance and monitoring.
• 58674 – laparoscopic surgical ablation of uterine fibroids, includes intraoperative ultrasound guidance and monitoring, with radiofrequency.
• 77427 – radiation oncology physician management
• 87468 – infectious agent detections
• 81418 – drug metabolism analysis using a genomic sequence
• 99202 – office or other outpatient visit for a new patient evaluation and management involving medically appropriate history and/or examination and straightforward medical decision-making, lasting at least 15 minutes.
• 99203 – office or other outpatient visit for a new patient evaluation and management, requiring medically appropriate history and/or examination and straightforward medical decision-making, lasting at least 30 minutes.
• 96446 – Chemotherapy administration into the peritoneal cavity via implanted port or catheter.

Tumor-Specific Codes

Here are tumor-specific CPT codes for 2024:

• 81455 – genomic sequence analysis panel for solid organ or hematolymphoid tumors or disorders, 51 or more genes, examining sequence variants, copy number variants, rearrangements, or isoform or mRNA expression levels, when conducted; includes either DNA alone or both DNA and RNA analysis.
• 81456 – targeted genomic sequence (RNA) analysis.
• 81457 – genomic sequence analysis panel for solid organ tumors, focusing on sequence variants; includes DNA analysis and evaluation for microsatellite instability.
• 81458 – DNA analysis for copy number variants and microsatellite instability.
• 81445 – genomic sequence analysis panel for solid organ tumors, 5–50 genes, assessing sequence variants, copy number variants, or rearrangements, if conducted; includes either DNA alone or both DNA and RNA analysis.
• 81449 – targeted genomic sequence (RNA) analysis.
• 81450 – genomic sequence analysis panel for hematolymphoid tumors or disorders, 5–50 genes, examining sequence variants, copy number variants, rearrangements, or isoform or mRNA expression levels, when conducted; includes either DNA alone or both DNA and RNA analysis.
• 81451 – targeted genomic sequence (RNA) analysis.
• 81455 – genomic sequence analysis panel for solid organ or hematolymphoid tumors or disorders, involving at least 51 genes; evaluates sequence variants, copy number variants or rearrangements, and may include isoform expression or mRNA expression levels; conducted via DNA analysis or a combination of DNA and RNA analysis.
• 81456 – targeted genomic sequence (RNA) analysis.
• 81457 – genomic sequence analysis panel for solid organ tumors, assessing sequence variants using DNA analysis, includes evaluation for microsatellite instability.
• 81458 – DNA analysis for identification of copy number variants and microsatellite instability.
• 81459 – combined DNA and RNA analysis or DNA analysis alone, examining copy number variants, microsatellite instability, tumor mutation burden, and rearrangements.

Liquid Biopsy Codes

Here are the 2024 CPT codes specifically for liquid biopsies:

• 81462 – genomic sequence analysis panel for solid organ tumors using cell-free nucleic acids (e.g., plasma), including sequence variant interrogation; involves DNA alone or both DNA and RNA analysis, and examines copy number variants and rearrangements.
• 81463 – DNA analysis focusing on copy number variants and microsatellite instability.
• 81464 – comprehensive DNA analysis or combined DNA and RNA analysis that includes copy number variants, microsatellite instability, tumor mutation burden, and rearrangements.

Hyperthermic Intraperitoneal Chemotherapy Codes

Here are the 2024 CPT codes specific to Hyperthermic Intraperitoneal Chemotherapy (HIPEC):

• +96547 – intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC), covering the first 60 minutes. Includes making separate incisions and closures if needed. Note: This code is used in addition to the primary procedure code.
• +96548 – additional intraoperative hyperthermic intraperitoneal chemotherapy, for each subsequent 30-minute interval. Note: This code is used in addition to the primary procedure code.

Oncology CPT Modifiers

CPT codes alongside any modifiers can improve the overall accuracy of medical billing. These are the updated oncology modifiers for 2024.

• FQ -service with audio-only communication
• FR -provider was present with audio-visual technology
• FS -split evaluation and management visit
• FT -E/M visit during a postoperative period
• 310 – not vaccinated against COVID-19
• 311 – partly vaccinated against COVID-19
• 39 – indicates any other under-immunized status

For informational purposes only.