Pathology CPT Codes and Modifiers for 2025
Apr 10, 2025
Pathology plays a critical role in diagnosis and disease monitoring—from tissue biopsies and Pap smears to molecular testing and autopsy services. To ensure timely and accurate reimbursement, labs and providers must stay current with Pathology CPT codes and modifiers for 2025.
Common Clinical Pathology Codes
| CPT Code | Description |
|---|---|
| 80050 | General health panel |
| 80053 | Comprehensive metabolic panel |
| 81001 | Urinalysis, automated, with microscopy |
| 82043 | Microalbumin, urine |
| 82565 | Creatinine, serum |
| 83036 | Hemoglobin A1c |
| 84443 | Thyroid-stimulating hormone (TSH) |
| 85025 | Complete blood count (CBC), automated with diff |
| 85610 | Prothrombin time (PT) |
| 86308 | H. pylori antibody test |
Anatomic Pathology Codes
| CPT Code | Description |
|---|---|
| 88300 | Gross exam only |
| 88304 | Surgical pathology, level III |
| 88305 | Surgical pathology, level IV |
| 88307 | Surgical pathology, level V |
| 88309 | Surgical pathology, level VI |
| 88142 | Pap smear, manual screening |
| 88175 | Pap smear, automated w/manual rescreen |
| 88341 | Immunohistochemistry, each additional antibody |
| 88360 | Morphometric analysis, quantitative |
| 88365 | In situ hybridization (e.g., FISH) |
Molecular Pathology & Genetic Testing
| CPT Code | Description |
|---|---|
| 81210 | BRAF gene analysis |
| 81235 | EGFR gene analysis |
| 81314 | KRAS gene mutation analysis |
| 81445 | Oncology targeted panel (5–50 genes) |
| 81450 | Exome sequencing, disease-specific |
| 81479 | Unlisted molecular pathology procedure |
Common Modifiers in Pathology Billing
| Modifier | Description |
|---|---|
| -26 | Professional component only |
| -TC | Technical component only |
| -90 | Reference (outside) laboratory |
| -91 | Repeat diagnostic lab test |
| -59 | Distinct procedural service |
| -77 | Repeat test by another provider |
| -92 | Alternative platform testing |
Common ICD-10 Codes in Pathology
| ICD-10 Code | Description |
|---|---|
| D50.9 | Iron deficiency anemia, unspecified |
| E11.9 | Type 2 diabetes without complications |
| C50.911 | Malignant neoplasm, right breast |
| N63 | Unspecified breast lump |
| R97.2 | Elevated PSA |
| R94.5 | Abnormal breast imaging findings |
| Z12.4 | Screening for cervical cancer |
| Z12.11 | Screening for colon cancer |
| Z13.0 | Screening for diabetes |
Pathology Billing Tips for 2025
Final Thoughts
Whether your lab is analyzing biopsies, running blood panels, or performing genetic sequencing, accuracy in coding ensures fair payment and audit readiness. Use this guide to stay current on Pathology CPT codes and modifiers for 2025 and optimize billing for every test, tissue, and report.
For informational purposes only.
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