Pathology CPT Codes for 2024 + Modifiers

Precision in billing is paramount within the realm of daily medical operations. Inaccurate coding within your pathology practice could lead to claim denials, underscoring the importance of striving for accuracy to optimize collection rates. Staying informed about the most recent CPT codes and modifiers is crucial to this endeavor

Pathology CPT Code Ranges for 2024

Here are 2024’s pathology CPT codes:

• 81418 – drug metabolism
• 81441 – inherited bone marrow failure syndromes
• 81449 – targeted genomic sequence analysis panel, solid organ neoplasm
• 81451 – targeted genomic sequence analysis panel
• 81456 – targeted genomic sequence analysis panel, solid organ or hematolymphoid neoplasm or disorder, 51 or greater genes
• 87468 – infectious agent detection by nucleic acid (DNA or RNA); Anaplasma phagocytophilum, amplified probe technique
• 87469 – infectious agent detection by nucleic acid (DNA or RNA); Babesia microti, amplified probe technique
• 87478 – infectious agent detection by nucleic acid (DNA or RNA); Borrelia miyamotoi, amplified probe technique
• 87484 – infectious agent detection by nucleic acid
• 87913 – infectious agent genotype analysis by nucleic acid
• 0285U – oncology, response to radiation
• 0287U – oncology (thyroid), DNA and mRNA
• 0288U – oncology (lung), mRNA, quantitative PCR analysis of 11 genes
• 2091U – psychiatry (mood disorders)
• 0292U – psychiatry (stress disorders)

2024 Digital Pathology Add-On CPT codes

Here are 2024’s new digital pathology add-on (+) CPT codes

• 88104+0827T – digitization of glass microscope slides for cytopathology, fluids, washings, or brushings, except cervical or vaginal, with interpretation.
• 88106+0828T – simple filter method for digitization of glass microscope slides for cytopathology, with interpretation.
• 88108+0829T – digitization of glass microscope slides for cytopathology, concentration technique, smears, and interpretation (e.g., Saccomanno technique).
• 88112+0830T – digitization of glass microscope slides for cytopathology, selective-cellular enhancement technique with interpretation, except cervical or vaginal.
• 88141+0831T – digitization of glass microscope slides for cytopathology, cervical or vaginal, requiring interpretation by physician.
• 88160+0832T – digitization of glass microscope slides for cytopathology, smears, any other source, screening, and interpretation.
• 88161+0833T – digitization of glass microscope slides for cytopathology, preparation, screening, and interpretation.
• 88162+0834T – extended study involving over 5 slides and/or multiple stains for digitization of glass microscope slides for cytopathology.
• 88172+0835T – immediate cytohistologic study to determine adequacy for diagnosis, first evaluation episode, each site.
• 88177+0836T – immediate cytohistologic study to determine adequacy for diagnosis, each separate additional evaluation episode, same site.
• 88173+0837T – interpretation and report for digitization of glass microscope slides for cytopathology.
• 88321+0838T – digitization of glass microscope slides for consultation and report on referred slides prepared elsewhere.
• 88323+0839T – digitization of glass microscope slides for consultation and report on referred material requiring preparation of slides.
• 88325+0840T – digitization of glass microscope slides for consultation, comprehensive, with review of records and specimens, with report on referred material.
• 88331+0841T – digitization of glass microscope slides for pathology consultation during surgery, first tissue block, with frozen section(s), single specimen
• 88332+0842T – each additional tissue block with frozen section(s) for digitization of glass microscope slides for pathology consultation during surgery.
• 88333+0843T – cytologic examination (e.g., touch preparation, squash preparation), initial site.
• 88334+0844T – cytologic examination (e.g., touch preparation, squash preparation), each additional site.
• 88346+0845T – digitization of glass microscope slides for immunofluorescence, per specimen, initial single antibody stain procedure.
• 88350+0846T – each additional single antibody stain procedure for digitization of glass microscope slides for immunofluorescence.
• 88363+0847T – digitization of glass microscope slides for examination and selection of retrieved archival tissue(s) for molecular analysis.
• 88365+0848T – digitization of glass microscope slides for in situ hybridization (e.g., FISH), per specimen, initial single probe stain procedure.
• 88364+0849T – each additional single probe stain procedure for digitization of glass microscope slides for in situ hybridization.
• 88366+0850T – each multiplex probe stain procedure for digitization of glass microscope slides for in situ hybridization.
• 88368+0851T – digitization of glass microscope slides for morphometric analysis, in situ quantitative or semiquantitative hybridization, manual, per specimen; initial single probe stain procedure.

Pathology CPT Modifiers

Modifiers play a crucial role in the daily routines of medical billing. When utilized correctly alongside the corresponding CPT codes, they enhance billing precision and reduce the likelihood of claim rejections. Below are the latest pathology modifier updates for 2024:

• -26 – professional component
• 24 – surgery or postoperative visit
• 88304 – benign diagnosis
• 88305 – malignant
• 310 – not vaccinated against COVID-19
• 311 – partly vaccinated against COVID-19
• 39 – indicates any other under-immunized status

For informational purposes only.